Ludogorets lost 0:2 away to Anderlecht from the main phase of the Europa League under a very controversial refereeing. Already in the first seconds, Dinis Almeida could have opened, but left alone after a corner kick, he did not find the target. Bonnman made a good save after Vazquez's header. With 20 minutes played, Son broke well down the left but couldn't quite find Caio Vidal. In the 29th minute, Ludogorets was one man down after a direct red card to Caio Vidal.

Anderlecht took the lead in the 68th minute. Versheeren sprung behind the defense and shot but Bonnman saved, after a series of ricochets the ball found its way to Edozi who opened the scoring. However, Ludogorets did not give up and scored a goal. It was the work of Rwan, who headed the ball home after Naressi hit the post. However, the goal was canceled due to an extremely thin offside by the captain of the Eagles. Shortly after, Anderlecht got a second goal, the work of Dreyer.

The Bulgarian champion was supported by over 1000 fans in the Belgian capital.