Ludogorets know already their opponents in the main phase of the Europa League. The 13-time champions will have home games against Czech Slavia (Prague), Dutch AZ Alkmaar, Danish Midtjylland and Spanish Athletic (Bilbao).
The Eagles will visit the Italian Lazio, the French Lyon, the Czech Victoria (Pilsen) and the Belgian Anderlecht.
Ludogorets has played with four of the listed opponents so far. These are Lazio, Victoria (Pilsen), Anderlecht and Midtjylland.